Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
RPE65Retinoid isomerohydrolase RPE65. (533 aa)    
Predicted Functional Partners:
RDH10
Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.936
DGAT1
O-acyltransferase.
   
 
 0.916
PNPLA4
PNPLA domain-containing protein.
     
 0.905
LOC102358735
O-acyltransferase.
   
 
 0.904
CEP290
Centrosomal protein 290.
      
 0.706
RPGRIP1
RPGR interacting protein 1.
     
 0.694
H2ZSE1_LATCH
Uncharacterized protein.
   
  
 0.657
AIPL1
Aryl hydrocarbon receptor interacting protein like 1.
      
 0.612
ASPM
Abnormal spindle microtubule assembly.
   
  
 0.606
CENPF
Centromere protein F.
   
  
 0.601
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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