Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LZTS1Leucine zipper tumor suppressor 1. (493 aa)    
Predicted Functional Partners:
UNC119
Unc-119 lipid binding chaperone.
    
   0.963
H3A6Z2_LATCH
GMP_PDE_delta domain-containing protein.
    
   0.909
LOC102356000
Uncharacterized protein.
    
   0.794
LZTS2
Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.
    
   0.794
SIPA1L2
Signal induced proliferation associated 1 like 2.
    
 
 0.794
FEZ2
Fasciculation and elongation protein zeta 2.
   
  
 0.600
PALMD
Palmdelphin.
      
 0.593
FLAD1
Flavin adenine dinucleotide synthetase 1.
      
 0.576
OSBP
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.574
LOC102350608
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.574
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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