Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase. (402 aa)    
Predicted Functional Partners:
ALG1
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase.
   
 0.997
ALG11
ALG11 alpha-1,2-mannosyltransferase.
   
0.983
PDCD6IP
Programmed cell death 6 interacting protein.
    
 
 0.958
MUS81
Uncharacterized protein.
   
 0.928
TSG101
Tumor susceptibility 101.
    
 
 0.902
FANCM
FA complementation group M.
   
 0.850
H3ASJ3_LATCH
Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family.
   
 
 0.848
ALG13
ALG13 UDP-N-acetylglucosaminyltransferase subunit.
    
 0.838
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 
 0.815
PMM2
Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.
   
 0.791
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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