Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
H2ZYH4_LATCHABC transmembrane type-1 domain-containing protein. (385 aa)    
Predicted Functional Partners:
LOC102365982
Uncharacterized protein.
 
      0.900
ABCC3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3.
 
      0.900
H3AES0_LATCH
ATP-binding cassette, sub-family C (CFTR/MRP), member 3.
     
 
0.900
GOPC
Golgi-associated PDZ and coiled-coil motif containing.
    
 0.508
KATNAL2
Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
  
 0.488
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.486
USP10
Ubiquitin carboxyl-terminal hydrolase.
    
  0.480
UBE2V2-2
Ubiquitin-conjugating enzyme E2 variant 2.
     
  0.464
UBE2V1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
     
  0.464
ITSN2
Intersectin 2.
    
 0.450
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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