Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IST1IST1 factor associated with ESCRT-III. (260 aa)    
Predicted Functional Partners:
CHMP2A
Charged multivesicular body protein 2A.
   
 0.988
LOC102356960
Charged multivesicular body protein 3.
    
 0.986
CHMP2B
Charged multivesicular body protein 2B.
   
 0.986
VTA1
Vta1 domain-containing protein.
   
 
 0.978
CHMP5
Charged multivesicular body protein 5.
   
 
 0.973
VPS4B
Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.
   
 0.970
VPS4A
Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family.
   
 0.970
CHMP6
Charged multivesicular body protein 6.
    
 0.959
APEH
Acylaminoacyl-peptide hydrolase.
    
 
 0.957
FIGN
Fidgetin, microtubule severing factor; Belongs to the AAA ATPase family.
    
 0.934
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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