Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SLC8A1-2J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (603 aa)    
Predicted Functional Partners:
SLC8A1
Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
 
     0.931
LOC102362951
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.
   
 
  0.900
PRKACB
Uncharacterized protein; Belongs to the protein kinase superfamily.
   
 
  0.900
H3AXI7_LATCH
Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
 
     0.589
KCNG2
Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family.
      
 0.573
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
   
  
 0.561
NKAIN1
Sodium/potassium transporting ATPase interacting 1.
   
  
 0.541
SCN4B
Sodium voltage-gated channel beta subunit 4.
   
  
 0.536
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
   
  
 0.500
AKAP1
A-kinase anchoring protein 1.
     
  0.495
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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