RASGEF1A protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RASGEF1A

RasGEF domain family member 1A. (475 aa)

Predicted Functional Partners:

RASA1

0.627

CCNK

0.529

SLC26A3

0.521

SOS1

0.518

LINGO1

0.508

HAUS8

0.503

UNC5D

0.476

H3AK75_LATCH

0.476

DLL3

0.454

DLL1

0.454

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNK	RASGEF1A	ENSLACP00000014682	ENSLACP00000002848	Cyclin K; Belongs to the cyclin family.	RasGEF domain family member 1A.	0.529
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
DLL1	H3AK75_LATCH	ENSLACP00000009351	ENSLACP00000010046	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ig-like domain-containing protein.	0.468
DLL1	RASGEF1A	ENSLACP00000009351	ENSLACP00000002848	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	RasGEF domain family member 1A.	0.454
DLL1	UNC5D	ENSLACP00000009351	ENSLACP00000008421	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ZU5 domain-containing protein.	0.468
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
DLL3	H3AK75_LATCH	ENSLACP00000008690	ENSLACP00000010046	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ig-like domain-containing protein.	0.468
DLL3	RASGEF1A	ENSLACP00000008690	ENSLACP00000002848	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	RasGEF domain family member 1A.	0.454
DLL3	UNC5D	ENSLACP00000008690	ENSLACP00000008421	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ZU5 domain-containing protein.	0.468
H3AK75_LATCH	DLL1	ENSLACP00000010046	ENSLACP00000009351	Ig-like domain-containing protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.468
H3AK75_LATCH	DLL3	ENSLACP00000010046	ENSLACP00000008690	Ig-like domain-containing protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.468
H3AK75_LATCH	RASGEF1A	ENSLACP00000010046	ENSLACP00000002848	Ig-like domain-containing protein.	RasGEF domain family member 1A.	0.476
H3AK75_LATCH	UNC5D	ENSLACP00000010046	ENSLACP00000008421	Ig-like domain-containing protein.	ZU5 domain-containing protein.	0.909
HAUS8	RASGEF1A	ENSLACP00000011226	ENSLACP00000002848	Uncharacterized protein.	RasGEF domain family member 1A.	0.503
LINGO1	RASGEF1A	ENSLACP00000009998	ENSLACP00000002848	Leucine rich repeat and Ig domain containing 1.	RasGEF domain family member 1A.	0.508
LINGO1	SLC26A3	ENSLACP00000009998	ENSLACP00000011041	Leucine rich repeat and Ig domain containing 1.	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.466
RASA1	RASGEF1A	ENSLACP00000005155	ENSLACP00000002848	RAS p21 protein activator 1.	RasGEF domain family member 1A.	0.627
RASA1	SOS1	ENSLACP00000005155	ENSLACP00000004382	RAS p21 protein activator 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.695
RASGEF1A	CCNK	ENSLACP00000002848	ENSLACP00000014682	RasGEF domain family member 1A.	Cyclin K; Belongs to the cyclin family.	0.529
RASGEF1A	DLL1	ENSLACP00000002848	ENSLACP00000009351	RasGEF domain family member 1A.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.454