Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NEDD4LE3 ubiquitin-protein ligase. (876 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase.
    
0.973
ITCH
E3 ubiquitin-protein ligase.
   
0.945
WWP1
E3 ubiquitin-protein ligase.
    
0.944
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.941
SMAD7
Mothers against decapentaplegic homolog.
    
 0.935
CBL
Cbl proto-oncogene.
    
 0.928
DLG3
Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.
    
 0.921
MDM2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
    
 0.919
SCNN1B
Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 0.918
SCNN1G
Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
    
 0.910
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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