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CTU2 protein (Latimeria chalumnae) - STRING interaction network
"CTU2" - Cytosolic thiouridylase subunit 2 homolog (S. pombe) in Latimeria chalumnae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CTU2Cytosolic thiouridylase subunit 2 homolog (S. pombe); Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (530 aa)    
Predicted Functional Partners:
CTU1
Cytosolic thiouridylase subunit 1 homolog (S. pombe); Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (341 aa)
     
  0.996
URM1
Ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifical [...] (101 aa)
     
  0.750
ALKBH8
alkB, alkylation repair homolog 8 (E. coli) (664 aa)
     
   
  0.743
WDR18
WD repeat domain 18 (431 aa)
     
   
  0.617
MOCS3
Molybdenum cofactor synthesis 3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated [...] (466 aa)
     
 
  0.608
OTOG
Otogelin (2804 aa)
       
      0.602
ELP3
Elongator acetyltransferase complex subunit 3 (640 aa)
     
 
  0.600
ENSLACG00000008143
Uncharacterized protein (422 aa)
     
   
  0.588
CNDP1
Carnosine dipeptidase 1 (metallopeptidase M20 family) (490 aa)
       
      0.582
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family) (474 aa)
       
      0.582
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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