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CTU2 protein (Latimeria chalumnae) - STRING interaction network
"CTU2" - Cytoplasmic tRNA 2-thiolation protein 2 in Latimeria chalumnae
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Predicted Interactions
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textmining
co-expression
protein homology
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CTU2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (530 aa)    
Predicted Functional Partners:
CTU1
Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (341 aa)
     
  0.998
MOCS3
Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide t [...] (466 aa)
     
 
  0.954
MPST
annotation not available (301 aa)
     
 
  0.953
NFS1
NFS1 cysteine desulfurase; NFS1 nitrogen fixation 1 (S. cerevisiae) (449 aa)
     
   
  0.946
URM1
Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifical [...] (101 aa)
     
 
  0.808
ALKBH8
AlkB homolog 8, tRNA methyltransferase; alkB, alkylation repair homolog 8 (E. coli) (664 aa)
     
   
  0.782
MCM5
DNA helicase; Minichromosome maintenance complex component 5; Belongs to the MCM family (635 aa)
     
   
  0.763
ELP2
Elongator acetyltransferase complex subunit 2 (897 aa)
     
   
  0.725
AATF
Apoptosis antagonizing transcription factor (555 aa)
     
        0.693
IMP4
IMP4, U3 small nucleolar ribonucleoprotein (291 aa)
     
        0.691
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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