Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Elongation factor RNA polymerase II (635 aa)
Predicted Functional Partners:
AF4/FMR2 family, member 4 (1163 aa)
ELL associated factor 1 (260 aa)
MLLT1, super elongation complex subunit; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (488 aa)
Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (258 aa)
ELL associated factor 2 (257 aa)
AF4/FMR2 family, member 1 (1215 aa)
Vacuolar protein sorting 36 homolog (S. cerevisiae) (261 aa)
Interactor of little elongator complex ELL subunit 2 (1009 aa)