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STRINGSTRING
PARP1 protein (Latimeria chalumnae) - STRING interaction network
"PARP1" - Poly in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PARP1Poly (ADP-ribose) polymerase 1 (1011 aa)    
Predicted Functional Partners:
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6 (610 aa)
     
 
  0.947
CASP3
Caspase 3, apoptosis-related cysteine protease a; Belongs to the peptidase C14A family (290 aa)
     
 
  0.906
ENSLACG00000006378
X-ray repair complementing defective repair in Chinese hamster cells 1 (649 aa)
     
 
  0.862
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (584 aa)
     
 
  0.860
WDTC1
WD and tetratricopeptide repeats 1 (646 aa)
     
   
  0.859
BRCA1
Uncharacterized protein; Breast cancer 1, early onset (1873 aa)
     
 
  0.838
RNF146
Ring finger protein 146 (347 aa)
       
 
  0.826
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family (401 aa)
     
 
  0.814
BRCA2
Uncharacterized protein; Breast cancer 2, early onset (1245 aa)
     
 
  0.814
CASP9
Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (457 aa)
     
 
  0.807
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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