Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC102346364Histone H2A; Belongs to the histone H2A family. (126 aa)    
Predicted Functional Partners:
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.965
AIFM1
Apoptosis inducing factor mitochondria associated 1.
    
  0.904
MYSM1
Myb like, SWIRM and MPN domains 1.
    
 0.875
H2ZZP4_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 0.850
RPS27A
Ribosomal protein S27a.
   
 0.850
H3A2S8_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 0.849
H2ZS39_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 0.822
LOC102361505
Histone H2B; Belongs to the histone H2B family.
 
 0.822
H2BE1
Histone H2B; Belongs to the histone H2B family.
 
 0.822
H3A5E7_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 0.821
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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