Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)    
Predicted Functional Partners:
TYMP
Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  
 
 0.997
CDA
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
  
 
 0.996
UCK1
Uridine-cytidine kinase; Belongs to the uridine kinase family.
    
 0.983
DPYD
Pyr_redox_2 domain-containing protein.
    
 0.979
TK2
Thymidine kinase 2.
     
 0.968
NT5E
5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.
    
 0.965
UCK2
Uridine-cytidine kinase 2.
    
 0.964
UMPS
Uridine monophosphate synthetase.
    
 0.963
LOC102362277
Uncharacterized protein; Belongs to the 5'-nucleotidase family.
    
 0.963
UCKL1
Uridine-cytidine kinase 1 like 1.
    
 0.945
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.