Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HOOK3Hook microtubule tethering protein 3. (709 aa)    
Predicted Functional Partners:
AKTIP
AKT interacting protein.
   
 
 0.983
DCTN1
Dynactin 1a.
    
 
 0.926
MCM4
DNA helicase; Belongs to the MCM family.
   
 
 0.921
DYNC1LI1
Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
    
 0.919
FAM160A2
Family with sequence similarity 160 member A2.
    
 
 0.905
FAM160A1
Family with sequence similarity 160 member A1.
    
 
 0.905
BICD1
BICD cargo adaptor 1.
   
 
 0.858
BICD2
BICD cargo adaptor 2.
   
 
 0.858
LOC102351176
Zgc:162200.
   
 
 0.823
DYNC1H1
Dynein cytoplasmic 1 heavy chain 1.
   
 
 0.813
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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