USP49 protein (Latimeria chalumnae) - STRING interaction network

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Score

USP49

Ubiquitin carboxyl-terminal hydrolase. (701 aa)

Predicted Functional Partners:

USP44

0.925

FKBP5

0.852

TAF9

0.829

TADA3

0.825

TAF10

0.817

CETN3

0.812

USP39

0.807

MED20

0.781

DSTYK

0.781

ENY2

0.747

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CETN3	ENY2	ENSLACP00000005971	ENSLACP00000014278	Centrin 3.	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	0.951
CETN3	USP44	ENSLACP00000005971	ENSLACP00000002218	Centrin 3.	Ubiquitin carboxyl-terminal hydrolase.	0.663
CETN3	USP49	ENSLACP00000005971	ENSLACP00000003101	Centrin 3.	Ubiquitin carboxyl-terminal hydrolase.	0.812
DSTYK	MED20	ENSLACP00000013905	ENSLACP00000005151	Dual serine/threonine and tyrosine protein kinase.	Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.815
DSTYK	USP49	ENSLACP00000013905	ENSLACP00000003101	Dual serine/threonine and tyrosine protein kinase.	Ubiquitin carboxyl-terminal hydrolase.	0.781
ENY2	CETN3	ENSLACP00000014278	ENSLACP00000005971	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	Centrin 3.	0.951
ENY2	TADA3	ENSLACP00000014278	ENSLACP00000000077	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	Transcriptional adaptor 3.	0.983
ENY2	TAF10	ENSLACP00000014278	ENSLACP00000004533	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.983
ENY2	TAF9	ENSLACP00000014278	ENSLACP00000009355	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	TATA-box binding protein associated factor 9.	0.979
ENY2	USP44	ENSLACP00000014278	ENSLACP00000002218	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	Ubiquitin carboxyl-terminal hydrolase.	0.747
ENY2	USP49	ENSLACP00000014278	ENSLACP00000003101	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	Ubiquitin carboxyl-terminal hydrolase.	0.747
FKBP5	USP44	ENSLACP00000022626	ENSLACP00000002218	Peptidylprolyl isomerase.	Ubiquitin carboxyl-terminal hydrolase.	0.526
FKBP5	USP49	ENSLACP00000022626	ENSLACP00000003101	Peptidylprolyl isomerase.	Ubiquitin carboxyl-terminal hydrolase.	0.852
MED20	DSTYK	ENSLACP00000005151	ENSLACP00000013905	Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Dual serine/threonine and tyrosine protein kinase.	0.815
MED20	TAF9	ENSLACP00000005151	ENSLACP00000009355	Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	TATA-box binding protein associated factor 9.	0.582
MED20	USP49	ENSLACP00000005151	ENSLACP00000003101	Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Ubiquitin carboxyl-terminal hydrolase.	0.781
TADA3	ENY2	ENSLACP00000000077	ENSLACP00000014278	Transcriptional adaptor 3.	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...]	0.983
TADA3	TAF10	ENSLACP00000000077	ENSLACP00000004533	Transcriptional adaptor 3.	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.999
TADA3	TAF9	ENSLACP00000000077	ENSLACP00000009355	Transcriptional adaptor 3.	TATA-box binding protein associated factor 9.	0.998
TADA3	USP44	ENSLACP00000000077	ENSLACP00000002218	Transcriptional adaptor 3.	Ubiquitin carboxyl-terminal hydrolase.	0.825