Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TCN2DUF4430 domain-containing protein. (431 aa)    
Predicted Functional Partners:
AMN
Amnion associated transmembrane protein.
     
 0.864
LRP2
LDL receptor related protein 2.
   
 0.783
CUBN
Cubilin.
    
 0.721
MTR
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
      
 0.682
TMEM37
Transmembrane protein 37.
   
  
 0.662
LDLRAP1
Low density lipoprotein receptor adaptor protein 1b.
     
  0.648
CYB561A3
Cytochrome b561 family member A3.
      
 0.641
LMBRD1
LMBR1 domain containing 1.
      
 0.641
SLC5A6
Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.639
MMUT
Methylmalonyl-CoA mutase.
      
 0.625
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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