Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG4BPleckstrin homology and RhoGEF domain containing G4B. (1440 aa)    
Predicted Functional Partners:
ARHGEF19
Rho guanine nucleotide exchange factor 19.
     
 0.751
ARHGEF33
DH domain-containing protein.
     
 0.745
ARHGEF11
Rho guanine nucleotide exchange factor 11.
     
 0.707
RASGRF2
Ras protein specific guanine nucleotide releasing factor 2.
     
 0.690
SPEG
Ig-like domain-containing protein.
     
 0.658
H2ZUX7_LATCH
DH domain-containing protein.
    
 0.577
PCYT2
Phosphate cytidylyltransferase 2, ethanolamine.
      
 0.526
PPWD1
Peptidylprolyl isomerase domain and WD repeat containing 1.
      
 0.467
ARHGAP1
Rho GTPase activating protein 1.
      
 0.454
ITSN2
Intersectin 2.
   
 0.430
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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