Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARRDC3Arrestin domain containing 3. (414 aa)    
Predicted Functional Partners:
WWP2
E3 ubiquitin-protein ligase.
    
 
 0.796
ITCH
E3 ubiquitin-protein ligase.
    
 
 0.790
AQP8
Aquaporin 8a, tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.779
WWP1
E3 ubiquitin-protein ligase.
    
 
 0.774
LOC102347712
Thioredoxin; Belongs to the thioredoxin family.
    
 0.741
AQP4
Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.706
CUEDC1
CUE domain containing 1.
    
   0.670
TSG101
Tumor susceptibility 101.
   
 
 0.582
D2HGDH
D-2-hydroxyglutarate dehydrogenase.
    
 
 0.581
NEDD4L
E3 ubiquitin-protein ligase.
    
 
 0.574
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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