Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CEP78Centrosomal protein 78. (673 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
     
 0.957
DDB1
Damage specific DNA binding protein 1.
    
 
 0.933
FGFR1OP
FGFR1 oncogene partner.
    
   0.928
UBR5
Ubiquitin protein ligase E3 component n-recognin 5.
    
 
 0.911
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.910
CEP290
Centrosomal protein 290.
    
 0.868
H3AUH3_LATCH
Uncharacterized protein.
    
 0.847
TMEM82
Transmembrane protein 82.
      
 0.791
LOC102364679
Centrin 4.
    
 0.783
H3AYK2_LATCH
Uncharacterized protein.
     
 0.753
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.