Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SCAPSREBF chaperone. (1283 aa)    
Predicted Functional Partners:
MBTPS1
Membrane bound transcription factor peptidase, site 1.
   
 
 0.964
SREBF2
Sterol regulatory element binding transcription factor 2.
    
 0.948
SREBF1
Sterol regulatory element binding transcription factor 1.
    
 0.948
INSIG2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
    
 0.902
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
    
 0.902
NPC2
NPC intracellular cholesterol transporter 2.
   
 0.804
H2ZTK5_LATCH
Peptidase_M50 domain-containing protein.
      
 0.791
MYCN
MYCN proto-oncogene, bHLH transcription factor.
    
 0.601
DHCR7
7-dehydrocholesterol reductase.
      
 0.593
KAT14
Lysine acetyltransferase 14.
      
 0.557
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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