Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LZTS2Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (678 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.917
LZTS1
Leucine zipper tumor suppressor 1.
    
   0.794
UNC79
Unc-79 homolog, NALCN channel complex subunit.
    
 0.712
DYRK1B
Dual specificity tyrosine phosphorylation regulated kinase 1B.
    
 
 0.559
DYRK1A
Dual specificity tyrosine phosphorylation regulated kinase 1A.
    
 
 0.559
CTNNBIP1
Catenin beta interacting protein 1.
      
 0.541
ARGLU1
Arginine and glutamate rich 1.
   
 0.533
LOC102345465
Uncharacterized protein.
    
 0.513
H3AN32_LATCH
Uncharacterized protein.
    
 0.513
CCDC22
Coiled-coil domain containing 22.
     
 0.488
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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