STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (245 aa)    
Predicted Functional Partners:
H2ZTT6_LATCH
Phosphoinositide phospholipase C.
     
 0.708
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
0.708
LOC102352804
Phosphoinositide phospholipase C.
     
0.654
FANCM
FA complementation group M.
    
 0.603
GRB2
Growth factor receptor bound protein 2.
     
 0.547
XPA
XPA, DNA damage recognition and repair factor.
     
 0.547
PIK3AP1
Phosphoinositide-3-kinase adaptor protein 1.
     
 0.525
AKAP6
Uncharacterized protein.
      
 0.524
GRAP2
GRB2 related adaptor protein 2.
     
0.518
USP8
Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.
     
 0.509
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.