Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
UVRAGUV radiation resistance associated. (407 aa)    
Predicted Functional Partners:
BECN1
Beclin 1, autophagy related.
    
 0.998
RUBCN
Rubicon autophagy regulator.
    
 0.996
PIK3R4
Phosphoinositide-3-kinase regulatory subunit 4.
    
 0.989
H3AS24_LATCH
Uncharacterized protein.
 
   
  0.989
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
   
 0.988
SH3GLB1
SH3 domain containing GRB2 like, endophilin B1.
    
 0.971
ATG14
Autophagy related 14.
    
 
 0.810
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.778
H3BFJ3_LATCH
VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.
    
 
 0.736
GABARAPL2
GABA type A receptor associated protein like 2.
     
 0.714
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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