Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
THOP1Thimet oligopeptidase 1. (684 aa)    
Predicted Functional Partners:
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
  
 0.612
LUM
Lumican.
      
 0.608
GRIN3A
Glutamate ionotropic receptor NMDA type subunit 3A.
      
 0.602
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain.
      
 0.597
CIB3
Calcium and integrin binding family member 3.
    
 
 0.596
NEDD9
Neural precursor cell expressed, developmentally down-regulated 9.
      
 0.594
WDR63
WD repeat domain 63.
      
 0.555
SYDE2
Synapse defective Rho GTPase homolog 2.
      
 0.552
MME
Membrane metalloendopeptidase.
      
 0.511
MMEL1
Membrane metalloendopeptidase like 1.
      
 0.511
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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