Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (284 aa)    
Predicted Functional Partners:
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 0.990
CYP7B1
Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.
   
 0.982
DHCR7
7-dehydrocholesterol reductase.
   
 0.968
LOC102354799
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 0.965
CYP7A1
Cytochrome P450 family 7 subfamily A member 1.
   
 0.965
LOC102364376
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 0.965
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.961
CYP46A1
Cytochrome P450 family 46 subfamily A member 1.
   
 0.958
IDI1
Isopentenyl-diphosphate delta isomerase 1.
  
  
 0.954
DHCR24
24-dehydrocholesterol reductase.
   
 
 0.950
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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