STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LONRF2LON peptidase N-terminal domain and ring finger 2. (777 aa)    
Predicted Functional Partners:
RPS27A
Ribosomal protein S27a.
   
  0.676
TRIP12
Thyroid hormone receptor interactor 12.
    
 0.618
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.608
UBE2N
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.599
PAXIP1
PAX interacting protein 1.
   
 0.577
BARD1
BRCA1 associated RING domain 1.
    
 0.571
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
     
 0.565
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
     
 0.555
LOC102350907
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.531
KXD1
Ubiquitin-like domain-containing protein.
    
 0.531
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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