Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PARP8Poly [ADP-ribose] polymerase. (775 aa)    
Predicted Functional Partners:
PGK1
Phosphoglycerate kinase.
  
 0.850
TPI1
Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
  
 
 0.800
GPI
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.790
RPS3
KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.
  
 
 0.776
ENO2
Enolase 2.
  
 0.763
ENO3
Enolase 3.
  
 0.763
ENO1
Enolase 1.
  
 0.763
RPL11
Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.
  
 
 0.755
MYCBPAP
MYCBP associated protein.
  
 0.745
RPS15
Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.
  
  0.738
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: medium (50%) [HD]