Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1287 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.999
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.996
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.996
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.991
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.988
CDON
Cell adhesion associated, oncogene regulated.
    
 0.988
SMURF2
E3 ubiquitin-protein ligase.
    
 0.987
GLI1
GLI family zinc finger 1.
   
 0.986
GAS1
Growth arrest specific 1.
     
 0.984
GLI2
GLI family zinc finger 2.
   
 0.981
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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