STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1287 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.998
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.997
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.996
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.992
LOC102356298
Uncharacterized protein.
     
 0.982
SMURF2
E3 ubiquitin-protein ligase.
    
 0.980
GLI1
GLI family zinc finger 1.
   
 0.907
LRP2
LDL receptor related protein 2.
     
 0.901
GLI3
GLI family zinc finger 3.
   
 0.891
GLI2
GLI family zinc finger 2.
   
 0.887
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.