STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1433 aa)    
Predicted Functional Partners:
SLF1
SMC5-SMC6 complex localization factor 1.
   
 0.992
H2ZWI5_LATCH
Uncharacterized protein.
  
 0.990
TOPBP1
DNA topoisomerase II binding protein 1.
   
 0.950
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
   
 0.938
BARD1
BRCA1 associated RING domain 1.
   
 0.938
GTF2H1
General transcription factor IIH subunit 1.
    
 0.935
LOC102353559
General transcription factor IIH subunit.
    
 0.933
BRCA1
BRCA1 DNA repair associated.
   
 0.932
GTF2H3
General transcription factor IIH subunit 3.
    
 0.931
MNAT1
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
    
 0.929
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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