Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SCML2Scm polycomb group protein like 2. (734 aa)    
Predicted Functional Partners:
CBX8
Chromobox 8.
    
  0.927
PCGF2
Polycomb group ring finger 2.
    
 0.893
BMI1
Bmi1 polycomb ring finger oncogene 1b.
    
 0.893
CBX2
Chromobox 2.
    
 0.863
RNF2
Ring finger protein 2.
    
 0.857
RING1
Ring finger protein 1.
    
 0.857
BCCIP
Protein BCCIP homolog; Belongs to the BCP1 family.
      
 0.823
CBX4
Chromobox 4.
    
  0.798
DOCK1
Dedicator of cytokinesis 1; Belongs to the DOCK family.
      
 0.788
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.780
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.