PAX8 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PAX8

Paired box 8. (458 aa)

Predicted Functional Partners:

H3A3M8_LATCH

0.821

TSHR

0.800

LHX1

0.769

EYA1

0.759

WT1

0.726

EYA4

0.715

EN1

0.706

GATA3

0.700

NKX2-1

0.698

FOXE1

0.696

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EN1	PAX8	ENSLACP00000019687	ENSLACP00000004228	Homeobox protein engrailed-like.	Paired box 8.	0.706
EYA1	PAX8	ENSLACP00000017557	ENSLACP00000004228	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 8.	0.759
EYA4	PAX8	ENSLACP00000004480	ENSLACP00000004228	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 8.	0.715
FOXE1	H3A3M8_LATCH	ENSLACP00000013926	ENSLACP00000004249	Forkhead box E1.	Uncharacterized protein.	0.484
FOXE1	NKX2-1	ENSLACP00000013926	ENSLACP00000018808	Forkhead box E1.	NK2 homeobox 1.	0.609
FOXE1	PAX8	ENSLACP00000013926	ENSLACP00000004228	Forkhead box E1.	Paired box 8.	0.696
FOXE1	TSHR	ENSLACP00000013926	ENSLACP00000018752	Forkhead box E1.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.587
GATA3	LHX1	ENSLACP00000003446	ENSLACP00000020589	GATA binding protein 3.	LIM homeobox 1.	0.602
GATA3	PAX8	ENSLACP00000003446	ENSLACP00000004228	GATA binding protein 3.	Paired box 8.	0.700
GATA3	WT1	ENSLACP00000003446	ENSLACP00000018599	GATA binding protein 3.	WT1 transcription factor.	0.434
H3A3M8_LATCH	FOXE1	ENSLACP00000004249	ENSLACP00000013926	Uncharacterized protein.	Forkhead box E1.	0.484
H3A3M8_LATCH	NKX2-1	ENSLACP00000004249	ENSLACP00000018808	Uncharacterized protein.	NK2 homeobox 1.	0.505
H3A3M8_LATCH	PAX8	ENSLACP00000004249	ENSLACP00000004228	Uncharacterized protein.	Paired box 8.	0.821
H3A3M8_LATCH	TSHR	ENSLACP00000004249	ENSLACP00000018752	Uncharacterized protein.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.921
LHX1	GATA3	ENSLACP00000020589	ENSLACP00000003446	LIM homeobox 1.	GATA binding protein 3.	0.602
LHX1	PAX8	ENSLACP00000020589	ENSLACP00000004228	LIM homeobox 1.	Paired box 8.	0.769
LHX1	WT1	ENSLACP00000020589	ENSLACP00000018599	LIM homeobox 1.	WT1 transcription factor.	0.520
NKX2-1	FOXE1	ENSLACP00000018808	ENSLACP00000013926	NK2 homeobox 1.	Forkhead box E1.	0.609
NKX2-1	H3A3M8_LATCH	ENSLACP00000018808	ENSLACP00000004249	NK2 homeobox 1.	Uncharacterized protein.	0.505
NKX2-1	PAX8	ENSLACP00000018808	ENSLACP00000004228	NK2 homeobox 1.	Paired box 8.	0.698