USP7 protein (Latimeria chalumnae) - STRING interaction network

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Score

USP7

Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)

Predicted Functional Partners:

UVSSA

0.998

DAXX

0.994

USP11

0.994

MDM2

0.991

TP53

0.991

FOXO4

0.986

GMPS

0.985

TRIP12

0.983

MDM4

0.982

CHEK1

0.974

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHEK1	MDM2	ENSLACP00000018986	ENSLACP00000011599	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.730
CHEK1	MDM4	ENSLACP00000018986	ENSLACP00000019637	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.735
CHEK1	TP53	ENSLACP00000018986	ENSLACP00000015915	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
CHEK1	USP7	ENSLACP00000018986	ENSLACP00000004236	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.974
DAXX	MDM2	ENSLACP00000001216	ENSLACP00000011599	Death-domain associated protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.989
DAXX	MDM4	ENSLACP00000001216	ENSLACP00000019637	Death-domain associated protein.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.886
DAXX	TP53	ENSLACP00000001216	ENSLACP00000015915	Death-domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980
DAXX	USP7	ENSLACP00000001216	ENSLACP00000004236	Death-domain associated protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.994
FOXO4	MDM2	ENSLACP00000010904	ENSLACP00000011599	Forkhead box O4.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.960
FOXO4	MDM4	ENSLACP00000010904	ENSLACP00000019637	Forkhead box O4.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.531
FOXO4	TP53	ENSLACP00000010904	ENSLACP00000015915	Forkhead box O4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.830
FOXO4	USP7	ENSLACP00000010904	ENSLACP00000004236	Forkhead box O4.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.986
GMPS	TP53	ENSLACP00000008506	ENSLACP00000015915	Guanine monophosphate synthase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.672
GMPS	USP7	ENSLACP00000008506	ENSLACP00000004236	Guanine monophosphate synthase.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.985
MDM2	CHEK1	ENSLACP00000011599	ENSLACP00000018986	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.730
MDM2	DAXX	ENSLACP00000011599	ENSLACP00000001216	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Death-domain associated protein.	0.989
MDM2	FOXO4	ENSLACP00000011599	ENSLACP00000010904	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Forkhead box O4.	0.960
MDM2	MDM4	ENSLACP00000011599	ENSLACP00000019637	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.999
MDM2	TP53	ENSLACP00000011599	ENSLACP00000015915	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
MDM2	USP7	ENSLACP00000011599	ENSLACP00000004236	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.991