Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BRD1Bromodomain containing 1. (1190 aa)    
Predicted Functional Partners:
MEAF6
MYST/Esa1 associated factor 6.
   
 0.990
BRPF3
Bromodomain and PHD finger containing 3.
   
 0.982
ING5
Inhibitor of growth family member 5.
    
 0.917
ING4
Inhibitor of growth family member 4.
    
 0.917
KAT6B
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.899
KAT6A
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.899
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.867
TCF20
Transcription factor 20.
   
 
 0.850
KAT8
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.833
KAT5
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.833
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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