STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OIP5Mis18 domain-containing protein. (257 aa)    
Predicted Functional Partners:
MIS18A
MIS18 kinetochore protein A.
   
 0.995
H3AB45_LATCH
SANTA domain-containing protein.
   
 0.961
CENPM
Uncharacterized protein.
   
 
 0.778
H2ZZ70_LATCH
Nucleolar and spindle associated protein 1.
   
  
 0.759
CENPN
Centromere protein N.
   
 
 0.753
SKA3
Spindle and kinetochore associated complex subunit 3.
   
  
 0.734
CENPI
Centromere protein I.
   
 
 0.725
CENPU
Centromere protein U.
   
 
 0.710
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
     
 0.706
CENPK
Centromere protein K.
   
 
 0.704
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.