STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4-2Protein kinase domain-containing protein. (789 aa)    
Predicted Functional Partners:
SHC3
SHC adaptor protein 3.
    
 0.974
SHC1
SHC adaptor protein 1.
    
 0.974
HBEGF
Heparin binding EGF like growth factor.
    
 0.970
NRG2
Neuregulin 2.
    
 0.969
SHC2
SHC (Src homology 2 domain containing) transforming protein 2.
    
 0.965
SHC4
SHC adaptor protein 4.
    
 0.965
LOC102348007
Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).
    
 0.961
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.961
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.958
BTC
EGF-like domain-containing protein.
    
 0.951
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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