Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
USP11Ubiquitin specific peptidase 11. (572 aa)    
Predicted Functional Partners:
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
   
 0.994
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.960
NFKBIA
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.
    
 0.938
RAE1
Ribonucleic acid export 1.
    
   0.899
LOC102356738
USP domain-containing protein; Belongs to the peptidase C19 family.
 
 
 0.859
ZUP1
Zinc finger containing ubiquitin peptidase 1.
   
 
 0.846
EIF4B
Eukaryotic translation initiation factor 4B.
   
 
 0.824
XPC
XPC complex subunit, DNA damage recognition and repair factor.
   
 
 0.823
H2ZYB4_LATCH
Uncharacterized protein.
    
 0.820
IFT43
Uncharacterized protein.
    
   0.745
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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