STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 0.999
H3ARU2_LATCH
Uncharacterized protein.
   
 0.970
HRAS
HRas proto-oncogene, GTPase.
   
 0.970
NRAS
NRAS proto-oncogene, GTPase.
   
 0.970
KRAS
KRAS proto-oncogene, GTPase.
   
 0.970
PTPN11
Protein tyrosine phosphatase non-receptor type 11.
    
 0.961
LOC102352712
Protein tyrosine phosphatase non-receptor type 11b.
    
 0.961
FGFR4
Fibroblast growth factor receptor.
    
 0.959
FGFR2
Fibroblast growth factor receptor.
    
 0.951
PDGFRB
Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.949
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.