Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEI4Meiotic double-stranded break formation protein 4. (292 aa)    
Predicted Functional Partners:
REC114
REC114 meiotic recombination protein.
    
 
 0.950
CENPQ
Uncharacterized protein.
      
 0.930
CENPV
Centromere protein V.
      
 0.705
PNKP
Polynucleotide kinase 3'-phosphatase.
    
 
 0.671
RNF212
Ring finger protein 212.
      
 0.600
SPO11
SPO11 initiator of meiotic double stranded breaks.
      
 0.590
H3AJK5_LATCH
Uncharacterized protein.
      
 0.589
MLH3
MutL homolog 3.
      
 0.509
PRDM7
PR/SET domain 7.
   
  
 0.487
MEI1
Meiotic double-stranded break formation protein 1.
      
 0.454
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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