Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H3A427_LATCHHistone H2B; Belongs to the histone H2B family. (137 aa)    
Predicted Functional Partners:
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.968
H2AX
Histone H2A; Belongs to the histone H2A family.
 
 0.895
H3F3B
Histone H3; Belongs to the histone H3 family.
 
 
 0.866
H3F3B-2
Histone H3; Belongs to the histone H3 family.
 
 
 0.864
H3A6T6_LATCH
Histone H2A; Belongs to the histone H2A family.
 
 0.856
H3B8N0_LATCH
Histone H2A; Belongs to the histone H2A family.
 
 0.856
LOC102355712
Histone H3; Belongs to the histone H3 family.
 
 
 0.849
LOC102351015
Histone H3.3.
 
 
 0.840
H3F3A
H3 histone, family 3A.
 
 
 0.834
LOC102346364
Histone H2A; Belongs to the histone H2A family.
 
 0.817
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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