STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN1Tyrosine-protein phosphatase non-receptor type. (439 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
    
 0.926
IRS4
Insulin receptor substrate 4.
    
 0.925
IRS1
Insulin receptor substrate 1.
    
 0.925
IRS2
Insulin receptor substrate 2.
    
 0.925
H3AZ86_LATCH
FERM domain-containing protein.
 
  
 0.904
JAK2
Tyrosine-protein kinase.
   
 0.797
MET
MET proto-oncogene, receptor tyrosine kinase.
    
 0.797
LOC102363504
Tyrosine-protein kinase.
   
 0.797
EPB41L4A
Erythrocyte membrane protein band 4.1 like 4A.
 
      0.764
LOC102358202
Tyrosine-protein kinase receptor.
   
 0.761
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.