Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)    
Predicted Functional Partners:
TGFBR1
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
0.999
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.999
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.999
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.997
LOC102352268
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.997
SMURF2
E3 ubiquitin-protein ligase.
    
 0.996
TGFBR3
Transforming growth factor beta receptor 3.
    
 0.992
SMAD2
Mothers against decapentaplegic homolog.
   
 0.988
SMAD3
Mothers against decapentaplegic homolog.
   
 0.988
SMAD7
Mothers against decapentaplegic homolog.
   
 0.984
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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