Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
UHRF2Uncharacterized protein. (541 aa)    
Predicted Functional Partners:
DNMT1
DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
   
 0.971
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
    
 
 0.846
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.806
PCLAF
PCNA clamp associated factor.
   
 
 0.796
H3ALV1_LATCH
Uncharacterized protein.
   
 
 0.774
PCNP
PEST proteolytic signal containing nuclear protein.
    
 
 0.712
DNMT3B
DNA methyltransferase 3 beta.
   
 0.708
DNMT3A
DNA methyltransferase 3 alpha.
   
 0.708
H3A8H2_LATCH
Uncharacterized protein.
    
 
 0.707
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.703
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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