Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRF2Interferon regulatory factor. (342 aa)    
Predicted Functional Partners:
IRF1
Interferon regulatory factor.
   
 0.821
IRF2BP2
Interferon regulatory factor 2 binding protein 2.
    
 
 0.755
IRF2BP1
Interferon regulatory factor 2 binding protein 1.
    
 
 0.652
IRF2BPL
Interferon regulatory factor 2 binding protein like.
    
 
 0.652
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.628
RFC3
Replication factor C subunit 3.
   
 
 0.600
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.598
PAXIP1
PAX interacting protein 1.
   
 
 0.585
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.530
H3BCG1_LATCH
SET domain-containing protein.
    
 0.529
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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