STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1263 aa)    
Predicted Functional Partners:
GAK
J domain-containing protein.
    
 0.968
SNX18
Sorting nexin.
     
 0.955
LOC102348007
Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).
     
 0.944
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
     
 0.944
INPP5E
Inositol polyphosphate-5-phosphatase E.
     
 0.929
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.924
PIKFYVE
Phosphoinositide kinase, FYVE-type zinc finger containing.
   
 
 0.920
INPP4B
Inositol polyphosphate-4-phosphatase type II B.
     
 0.914
INPP4A
Inositol polyphosphate-4-phosphatase type I A.
     
 0.914
PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.
  
  
0.910
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.