Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PARP2Poly [ADP-ribose] polymerase. (502 aa)    
Predicted Functional Partners:
APLF
FHA_2 domain-containing protein.
    
 
 0.985
XRCC6
X-ray repair cross complementing 6.
   
 
 0.981
POLB
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
    
 0.981
RNF146
Ring finger protein 146.
    
 
 0.976
PARP3
Poly [ADP-ribose] polymerase.
  
 
0.974
XPC
XPC complex subunit, DNA damage recognition and repair factor.
   
 0.973
CHD1L
Chromodomain helicase DNA binding protein 1 like.
    
 0.968
PARG
Poly(ADP-ribose) glycohydrolase.
    
 0.952
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.943
LOC102367521
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.943
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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