IPO8 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

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[Homology]

Score

IPO8

Importin 8. (1016 aa)

Predicted Functional Partners:

KPNB1

0.992

IPO5

0.986

IPO4

0.983

IPO9

0.973

TNPO1

0.972

TNPO2

0.972

IPO13

0.947

RAN

0.936

IPO7

0.903

H2ZVK6_LATCH

0.865

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2ZVK6_LATCH	IPO7	ENSLACP00000001427	ENSLACP00000020013	Uncharacterized protein; Belongs to the argonaute family.	Importin 7.	0.865
H2ZVK6_LATCH	IPO8	ENSLACP00000001427	ENSLACP00000004697	Uncharacterized protein; Belongs to the argonaute family.	Importin 8.	0.865
H2ZVK6_LATCH	RAN	ENSLACP00000001427	ENSLACP00000021390	Uncharacterized protein; Belongs to the argonaute family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.632
IPO13	IPO4	ENSLACP00000018934	ENSLACP00000001599	Importin 13.	Importin 4.	0.986
IPO13	IPO5	ENSLACP00000018934	ENSLACP00000017413	Importin 13.	Importin 5.	0.966
IPO13	IPO7	ENSLACP00000018934	ENSLACP00000020013	Importin 13.	Importin 7.	0.947
IPO13	IPO8	ENSLACP00000018934	ENSLACP00000004697	Importin 13.	Importin 8.	0.947
IPO13	IPO9	ENSLACP00000018934	ENSLACP00000014591	Importin 13.	Importin 9.	0.962
IPO13	KPNB1	ENSLACP00000018934	ENSLACP00000020047	Importin 13.	Karyopherin subunit beta 1.	0.955
IPO13	RAN	ENSLACP00000018934	ENSLACP00000021390	Importin 13.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.931
IPO13	TNPO1	ENSLACP00000018934	ENSLACP00000013856	Importin 13.	Transportin 1.	0.950
IPO13	TNPO2	ENSLACP00000018934	ENSLACP00000013996	Importin 13.	Transportin 2.	0.950
IPO4	IPO13	ENSLACP00000001599	ENSLACP00000018934	Importin 4.	Importin 13.	0.986
IPO4	IPO5	ENSLACP00000001599	ENSLACP00000017413	Importin 4.	Importin 5.	0.994
IPO4	IPO7	ENSLACP00000001599	ENSLACP00000020013	Importin 4.	Importin 7.	0.983
IPO4	IPO8	ENSLACP00000001599	ENSLACP00000004697	Importin 4.	Importin 8.	0.983
IPO4	IPO9	ENSLACP00000001599	ENSLACP00000014591	Importin 4.	Importin 9.	0.990
IPO4	KPNB1	ENSLACP00000001599	ENSLACP00000020047	Importin 4.	Karyopherin subunit beta 1.	0.991
IPO4	RAN	ENSLACP00000001599	ENSLACP00000021390	Importin 4.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.768
IPO4	TNPO1	ENSLACP00000001599	ENSLACP00000013856	Importin 4.	Transportin 1.	0.987