Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CUL4ACullin 4A; Belongs to the cullin family. (851 aa)    
Predicted Functional Partners:
DDB1
Damage specific DNA binding protein 1.
   
 0.990
RBX1
Ring-box 1.
    
 0.976
CRBN
Cereblon.
    
 0.970
H3AN30_LATCH
Ddb1 and cul4 associated factor 11.
    
 0.966
NEDD8
NEDD8 ubiquitin like modifier.
    
 0.963
DTL
Denticleless E3 ubiquitin protein ligase homolog.
    
 0.963
ERCC8
ERCC excision repair 8, CSA ubiquitin ligase complex subunit.
    
 0.963
DDA1
DET1 and DDB1 associated 1.
    
 0.953
WDTC1
WD and tetratricopeptide repeats 1.
    
 0.949
COPS5
COP9 signalosome subunit 5.
    
 0.948
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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