Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TTC4Tetratricopeptide repeat domain 4. (398 aa)    
Predicted Functional Partners:
HGH1
HGH1 homolog.
   
 
 0.967
VPS29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
    
   0.944
VPS35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
    
   0.942
VPS26A
VPS26, retromer complex component A.
    
   0.928
CHORDC1
Cysteine and histidine rich domain containing 1.
    
 
 0.920
EDRF1
Erythroid differentiation regulatory factor 1.
    
   0.902
TTC5
Tetratricopeptide repeat domain 5.
  
 
 0.761
LOC102357218
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.
   
 0.719
HSP90AB1
Heat shock protein 90 alpha family class B member 1.
   
 0.719
HSP90AA1
Heat shock protein 90 alpha family class A member 1.
   
 0.719
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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