Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ESM1Endothelial cell specific molecule 1. (185 aa)    
Predicted Functional Partners:
CDH5
Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.
      
 0.794
KCNE3
Uncharacterized protein.
      
 0.644
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
      
 0.633
EFNB2
Ephrin B2; Belongs to the ephrin family.
      
 0.516
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
     
 0.483
ANGPT2
Angiopoietin 2.
   
  
 0.476
MESD
Mesoderm development LRP chaperone.
      
 0.471
COL8A1
Collagen type VIII alpha 1 chain.
     
 0.465
PLXND1
Plexin D1.
     
 0.463
OGA
O-GlcNAcase.
      
 0.462
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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