CLDN18 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

CLDN18

Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (276 aa)

Predicted Functional Partners:

ITGA4

0.930

CLDN16

0.881

LOC102346674

0.825

TTC14

0.811

PLK1

0.794

THBS1

0.789

DNAJC19

0.769

KCNE2

0.761

LOC102362450

0.743

CLDN1

0.724

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN1	CLDN16	ENSLACP00000017569	ENSLACP00000018273	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.788
CLDN1	CLDN18	ENSLACP00000017569	ENSLACP00000004903	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.724
CLDN1	LOC102362450	ENSLACP00000017569	ENSLACP00000020610	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.760
CLDN16	CLDN1	ENSLACP00000018273	ENSLACP00000017569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 1.	0.788
CLDN16	CLDN18	ENSLACP00000018273	ENSLACP00000004903	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.881
CLDN16	LOC102362450	ENSLACP00000018273	ENSLACP00000020610	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.656
CLDN18	CLDN1	ENSLACP00000004903	ENSLACP00000017569	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 1.	0.724
CLDN18	CLDN16	ENSLACP00000004903	ENSLACP00000018273	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.881
CLDN18	DNAJC19	ENSLACP00000004903	ENSLACP00000012693	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	DnaJ heat shock protein family (Hsp40) member C19.	0.769
CLDN18	ITGA4	ENSLACP00000004903	ENSLACP00000016373	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.930
CLDN18	KCNE2	ENSLACP00000004903	ENSLACP00000015984	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.761
CLDN18	LOC102346674	ENSLACP00000004903	ENSLACP00000021449	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.825
CLDN18	LOC102362450	ENSLACP00000004903	ENSLACP00000020610	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
CLDN18	PLK1	ENSLACP00000004903	ENSLACP00000004640	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Serine/threonine-protein kinase PLK.	0.794
CLDN18	THBS1	ENSLACP00000004903	ENSLACP00000020712	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Thrombospondin 1.	0.789
CLDN18	TTC14	ENSLACP00000004903	ENSLACP00000014102	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tetratricopeptide repeat domain 14.	0.811
DNAJC19	CLDN18	ENSLACP00000012693	ENSLACP00000004903	DnaJ heat shock protein family (Hsp40) member C19.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.769
DNAJC19	TTC14	ENSLACP00000012693	ENSLACP00000014102	DnaJ heat shock protein family (Hsp40) member C19.	Tetratricopeptide repeat domain 14.	0.870
ITGA4	CLDN18	ENSLACP00000016373	ENSLACP00000004903	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.930
ITGA4	LOC102346674	ENSLACP00000016373	ENSLACP00000021449	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.401

page 1 of 2

Server load: low (18%) [HD]

Permalink

Network

Fusion

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Neighborhood

© STRING Consortium 2026

Credits

Access

Info

About